There is a certain demystification of the natural world that occurs as our scientific knowledge increases. Every time something is analyzed, classified, and put in a book we seem to have gained mastery over a new piece of reality; it is somehow inferior to us now because we have successfully understood it to at least some degree. Some ancient people worshiped stars, for example, but modern man knows what stars really are and therefore does not worship them. Once we can relate to something as knower to known the object of our knowledge is somehow conquered or less than us in some way. Fear, wonder, and awe are reduced as a result of us possessing true knowledge of things. If an entire galaxy can somehow be known then there is a sense in which even the stars and planets can fit within our heads with ease.
This is the glory of metaphysics and theology, that any real metaphysical or theological knowledge we possess demonstrates definitively at least one thing: We are the masters of nothing. As creatures and as objects belonging to the finite world, our vast knowledge of the entire universe is completely insignificant when compared with the knowledge we have of things that are not of the physical world. It is not a matter of degree. To know that God exists, to know that the angelic universe exists, to know that all the things we see and touch are secondary to the higher being that is our creator, this is knowledge that can never make us masters. This is the knowledge that makes us servants, the knowledge that gives us fear, wonder, and awe. To truly know the star is to cease worship of it; to truly know God is to begin to fall prostrate before Him in praise.